News article from Sep. 27, 2021: 'Self-replicating protocells created in lab may be life's "missing link" ' (see https://newatlas.com/biology/self-replicating-protocells-life-missing-link/ )! Holy science!
Do you understand a 'geek' language? If so, then you will be pleased to know that the above mentioned news article has a link the full scientific article published in the science journal called "Nature". The abstract of the journal article says the following.
"The hypothesis that prebiotic molecules were transformed into polymers that evolved into proliferating molecular assemblages and eventually a primitive cell was first proposed about 100 years ago. To the best of our knowledge, however, no model of a proliferating prebiotic system has yet been realised because different conditions are required for polymer generation and self-assembly. In this study, we identify conditions suitable for concurrent peptide generation and self-assembly, and we show how a proliferating peptide-based droplet could be created by using synthesised amino acid thioesters as prebiotic monomers. Oligopeptides generated from the monomers spontaneously formed droplets through liquid–liquid phase separation in water. The droplets underwent a steady growth–division cycle by periodic addition of monomers through autocatalytic self-reproduction. Heterogeneous enrichment of RNA and lipids within droplets enabled RNA to protect the droplet from dissolution by lipids. These results provide experimental constructs for origins-of-life research and open up directions in the development of peptide-based materials."
Do you understand that? I only partially understand it, but it reminds me of what I had read about proteinoid microspheres and coacervate droplets and the journal article talks about both.
For information about proteinoid microspheres see https://en.wikipedia.org/wiki/Proteinoid . That Wikipedia article contains a quote from Our amazing world of Nature: its marvels & mysteries of Colin Pittendrigh . Before reading the Wikipedia article I had been reading my copy of the "Our Amazing ..." book and its quote of Colin. It looks like the experiment of creating self-replicating protocells, as reported in the recent "Nature" journal article, comes close to creating a living cell! Yippie!
For information about coacervate droplets see see https://en.wikipedia.org/wiki/Coacervate . For information about protocells see https://en.wikipedia.org/wiki/Protocell . That article (at least when accessed today) says "a functional protocell has not yet been achieved in a laboratory
setting, the goal to understand the process appears well within reach" but it was written before the above mentioned "Nature" article was published.